General Cell Based Assays
Eurofins Discoverx PathHunter Human IkB Degradation Cell-Based Assay Kit (Jurkat)
The PathHunter Human IkB Degradation Stable Cell Line Assay (Jurkat) measures pathway activation-induced degradation of IκB target protein. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress GALR1 Total Internalization Assay, 10pl Kit. (93-0781E3CP5L)
The PathHunter GALR1 Total Internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of GALR1 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged GALR1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the GALR1 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CRTH2 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0291E2CP2L)
The PathHunter CRTH2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prostaglandin D2) based activation of CRTH2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CRTH2 and EA-tagged β-Arrestin-2. Activation of CRTH2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress ADRA2B CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0641E2CP2L)
The PathHunter ADRA2B eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. epinephrine and norepinephrine) based activation of ADRA2B GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged ADRA2B and EA-tagged β-Arrestin-2. Activation of ADRA2B stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress OPN5 CHO-K1 β-Arrestin Orphan GPCR Assay, 2-Plate Kit. (93-0704E2CP1M)
The PathHunter OPN5 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of OPN5 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged OPN5 and EA-tagged β-Arrestin-2. Activation of OPN5 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Sigma Aldrich Fine Chemicals Biosciences Sulfate Assay Kit sufficie
Inorganic sulfate is one of the most abundant anions in mammalian plasma. Sulfate plays important physiological roles in activating and detoxifying xenobiotics steroids neurotransmitters and bile acids. Sulfate is needed for the biosynthesis of cerebroside sulfate glycosaminoglycans and heparin sulfate. Undersulfation of cartilage proteoglycans has been associated with human inherited osteochondro-dysplasia disorders. In mammals sulfate homeostasis is regulated by the kidney. The majority of filtered sulfate is absorbed in the proximal tubules and only 5-20% of the filtered load is excreted into the urine.
Eurofins Discoverx cAMP Hunter eXpress rDRD2L (Long Isoform) CHO-K1 GPCR Assay, 2pl Kit. (95-0130E2CP2M)
The cAMP Hunter rDRD2L eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. dopamine, pergolide) based activation of rDRD2L GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type rDRD2L, a naturally Gi/Go coupled GPCR. Upon activation of rDRD2L, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Rat version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress mCX3CR1 CHO-K1 β-Arrestin GPCR Assay, 10pl Kit. (93-0702E2MCP2L)
The PathHunter mCX3CR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CX3CL1, fractalkine) based activation of mCX3CR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mCX3CR1 and EA-tagged β-Arrestin-2. Activation of mCX3CR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc HTRF Total Histone H3 Detection Kit, Control Lysate
HTRF Total Histone H3 Detection Kit, Control Lysate
Eurofins Discoverx cAMP Hunter eXpress CCR5 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0068E2CP2L)
The cAMP Hunter CCR5 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CCL3) based activation of CCR5 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CCR5, a naturally Gi/Go coupled GPCR. Upon activation of CCR5, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cusabio Technology LLC kallikrein-related peptidase 5
This ELISA kit is designed for the quantitative detection of Human Kallikrein-5 (KLK5) in diverse biological samples including serum plasma cell culture supernatants tissue homogenates and saliva Utilizing a sandwich assay format the kit offers a broad detection range of 62 5 pg/mL to 4000 pg/mL with a sensitivity of 15 6 pg/mL ensuring precise measurement of KLK5 concentrations The assay requires only 50-100 L of sample per test and delivers results within 1-5 hours Detection is performed at 450 nm providing reliable and reproducible data for research applications This kit is optimized for accuracy and efficiency making it suitable for studies requiring sensitive quantification of KLK5 in multiple sample matrices
Eurofins Discoverx PathHunter eXpress GPR143 CHO-K1 β-Arrestin Orphan GPCR Assay, 2-Plate Kit. (93-0362E2ACP1M)
The PathHunter GPR143 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR143 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR143 and EA-tagged β-Arrestin-2. Activation of GPR143 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Abcam Thiol Green Indicator WS.
Thiol Green Indicator WS.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter Mouse GPR84 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Mouse GPR84 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure mGPR84 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Mouse RXFP3 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Mouse RXFP3 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure mRXFP3 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.